Arteriovenous malformations are masses of abnormal blood vessels that grow in the brain. They consist of a blood vessel "nidus" (nest) through which arteries connect directly to veins, instead of through the elaborate collection of very small vessels called capillaries. Some people are born with the nidus, but as the years go by, it tends to enlarge as the great pressure of the arterial vessels can not be handled by the veins that drain out of it. This causes a large collection of worm-like vessels to develop (malformed) into a mass capable of bleeding at some future time. These malformations are most likely to bleed between the ages of 10 - 55; after 55, the chances of bleeding diminishes rapidly. Before 55, the likelihood of hemorrhaging is between 3 and 4% per year (with a death incidence of about 1%). Once an AVM patient has hemorrhaged, the risk of having another one might approach 20% during the first year, and gradually lessen to about 3 - 4% over the next few years.
AVM s can occur in any area of the brain and can be either small or large. When they hemorrhage, they usually do so with a limited amount of blood, unlike the hypertensive hemorrhages of other stroke patients. The loss of neurologic function depends on both the location of the AVM and the amount of bleeding. Many patients have very small hemorrhages, often multiple. They may display convulsions before even knowing about the presence of an AVM. Some patients suffer from headaches, often unrelated to the AVM which is usually found with a CT scan or brain MRI. In rare instances, children are born with large AVM's and are found to have heart failure because the malformation makes the heart work beyond its capacity.
These lesions are surrounded by a very discrete layer of abnormal, nonfunctioning brain tissue, thus allowing their removal with relative safety to the surrounding brain. This factor is of the utmost importance to the brain surgeon, who can take advantage of this natural separation between normal brain tissue and the abnormal vascular malformation.
TREATMENT OPTIONS
Radiation
If there is a very small AVM, and it is deep-seated in the brain, the patient is fortunate. It is possible to give focused beam radiation to the malformation and avoid surgery. Within two years the malformation will most likely disappear.
Embolization
Larger malformations may be made more surgically manageable with a technique called embolization. With this procedure, an angiogram becomes a therapeutic tool. The interventional angiographer is capable of filling the malformation with agents which help decrease the blood supply to the malformation (coils, glues, plastic spheres, balloons, etc). This makes surgery easier in some cases. The technique has been used as the primary treatment as well and has apparently been successful in some cases.
Surgery
Perhaps surgery is still the best way to go if the decision has been made to do something to eliminate the AVM for good. Surgery cures these lesions by totally removing them, thus disallowing them from ever recurring again. The author's personal bias (quite strongly held) is that most AVMs are best cared for with surgical removal. Even with patients who have large and complex AVMs, surgery provides the cure when the malformation is completely removed.
Benefits of surgery
A team of specialists in all the disciplines are present to make an accurate diagnosis and arrive at the best course of action to eradicate the disease. Since the success of your surgery is largely dependent on your choice of surgeon, the objective of the doctor is to provide appropriate pre and post-surgery care.
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